Chronic disease is a leading cause of mortality and morbidity worldwide. Dietary intake is a significant modifiable risk factor in the development of chronic diseases, however, current nutrition approaches are failing to effect significant changes. In recent years, strategies identified to decrease diet-related chronic disease burden have included personalized approaches to nutrition. Nutritional genomics, or nutrigenomics, which investigates how nutrients and bioactive food compounds affect human health through epigenetic modifications, enables customization of an individual’s dietary intake at a given life stage to prevent or delay deterioration of health. Although diet personalization based on nutrigenomic understanding is part of the next health system paradigm, its uptake has stalled as most do not understand the science and how to apply it. To help address these knowledge gaps, a nutrigenomics and personalized open access course is proposed. The course would be partly delivered through digital reality environments (e.g., student as an avatar would examine a 3-D DNA helix and epigenetic effects from different diet exposures). This course aimed at university students with a basic understanding of biology and genetics.